Which of the following must be true when you help a person with his or her medication?

When assisting someone with their medication, it is essential that the person is responsive. This means they are alert and able to communicate effectively, which is crucial for ensuring their safety and understanding of what medication they are taking. A responsive individual can express their needs, confirm their identity, and provide any necessary information about their medical history or allergies that may affect medication administration. Being responsive also allows for better interaction, where you can assess their understanding and willingness to take the medication.

The other options, while they may have relevance in certain contexts, do not apply universally as requirements for helping with medication. For example, a prescription is important for legality and appropriateness, but in an emergency or specific circumstances, someone may need assistance without a formal prescription being shown. Similarly, while having a witness can be a good practice in many situations, it is not a strict requirement in every case, especially in urgent scenarios. Lastly, familiarity with the medication is beneficial, but it is not strictly necessary; what matters is the person's response and understanding at the moment of assistance.